Advice to the media
Monday, January 25, 2021
What
Contrary to previous findings, low-dose aspirin therapy before conception and during early pregnancy may increase the chances of pregnancy and live births among women who have experienced one or two previous miscarriages, a study suggests. conducted by researchers from the National Institutes of Health. Instead of looking solely at the difference in pregnancy rates between women who received aspirin and those who received a placebo, the study also looked at differences in total aspirin consumption among women who received they deviated from the daily regimen and those who adhered to it.
The research team was led by Enrique Schisterman, PhD, from the epidemiology branch of NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and colleagues. Appears in the file Annals of Internal Medicine.
Published in 2014, the study Effects of Aspirin on Pregnancy and Reproduction (EAGeR) included more than 1,000 women between the ages of 18 and 40 with one or two previous miscarriages. Women received low-dose daily aspirin (81 milligrams) or a placebo while trying to conceive. If conceived, they would continue to receive this regime until 36th week of pregnancy. Although the study found no overall difference in pregnancy loss rates between the two groups, there was a higher birth rate for the subgroup of women who had only experienced a previous miscarriage before pregnancy. twentieth week of pregnancy.
Unlike the original analysis, the current reanalysis considered whether a participant adhered to treatment or skipped the days or suspended it completely for side effects such as bleeding, nausea, or vomiting. Compared to the placebo group, for every 100 women, adherence to the aspirin regimen for five to seven days a week resulted in eight more positive pregnancy tests, six fewer pregnancy losses, and culminated in 15 births. you live longer. Women who adhered to therapy four days a week obtained similar results. The researchers concluded that taking low-dose aspirin at least four days a week could improve the chances of pregnancy and live birth in this group of women.
WHO
Lindsey Sjaarda, Ph.D., a staff scientist in the NICHD epidemiology branch, is available to comment.
h3> Article
Naimi, AI, et al. The effect of low-dose aspirin-initiated preconception on pregnancy, pregnancy loss, and live birth detected by human chorionic gonadotropin: by protocol analysis of a randomized trial. Annals of Internal Medicine. 2021.
About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD conducts research and training to understand human development, improve reproductive health, improve the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov.
Regarding the National Institutes of Health (NIH):
NIH, the country’s medical research agency, includes 27 institutes and centers and is a component of the U.S. Department of Health and Human Services. NIH is the leading federal agency that conducts and supports basic, clinical, and translational medical research, and investigates the causes, treatments, and cures for common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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