- A team of researchers from Japan may have discovered the cure for baldness.
- The RIKEN Center for Biosystems Dynamics Research used stem cells and a specific culture mechanism to create hair follicles that can recycle hair just like natural follicles.
- Any hair regeneration treatment should produce hair that can grow back after falling out. Stem cell therapy provided hair follicles that went through at least three hair production cycles of normal hair in laboratory tests.
Many people have tried to cure a medical condition that affects millions of people around the world, with men predominantly affected by the disease. Baldness can be triggered by specific pharmacological therapies, such as cancer treatment, and some COVID-19 survivors have found that hair loss is an unusual symptom. But baldness occurs in many others without a specific trigger. At age 35, two-thirds of American men will experience some degree of hair loss, according to the American Hair Loss Association. At age 50, up to 85% of men will experience significant hair thinning.
Baldness does not affect one’s health, but it can extract an emotional toll on those affected by it. There are several therapies for baldness, but there is no cure that can reverse the process. Now, however, a team in Japan could have found a solution to restore hair growth with the help of stem cells.
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The researchers used stem cells to create hair follicles that can grow hair after it falls out. This is how hair growth should work. Hair loss is natural, but each strand of hair must be replaced with a new one that grows back into place. Scientists at the RIKEN Center for Biosystems Dynamics Research published an article in Scientific reports on nature (via Futurism) detailing their progress with stem cells in mammals.
They took skin cells and mouse whiskers and then cultured them in the lab along with other ingredients. They used 220 combinations, finding that a type of collagen combined with five factors (mean NFFSE) would lead to the highest stem cell amplification rate in the shortest period of time. The RIKEN team explained that a successful hair regeneration treatment that could cure baldness should produce hair that is recycled. This means that hair can grow back after falling out naturally.
These researchers combined the stem cells of the bioengineered hair follicle with the NFFSE medium, as well as with the medium missing one of the ingredients. They observed regenerated hair for three weeks and found that the NFFSE medium allowed hair follicles to go through at least three cycles of normal hair production. The other medium was not as effective, as 79% of the follicles produced only one hair cycle.
The researchers also found that a specific marker on the surface of cells cultured in the NFFSE medium favored the hair cycle. “We found that almost 80% of the follicles reached three hair cycles when Itgβ5 was also bioengineered into the hair follicle germ,” the author said in a statement. “In contrast, only 13% reached three cycles when they were not there.”
“Our culture system establishes a method for the cyclic regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the future. next, ”said Takashi Tsuji, the study’s lead author.
Before this cure for baldness is commercially available, it must pass clinical trials. To date, RIKEN researchers have demonstrated stem cell therapy in preclinical laboratory tests. Tsuji said the institute is looking for external collaborators to help develop clinical applications for the new hair growth technology.
The full study is available at this link.
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Chris Smith began writing about gadgets as a hobby, and before he knew it, he was sharing his views on technology issues with readers around the world. Whenever he doesn’t write about gadgets, he fails to stay away from them, even though he tries desperately. But that’s not necessarily a bad thing.