The “atlas” of skin cells sheds light on how psoriasis and eczema develop

by

The “atlas” of skin cells sheds light on how psoriasis and eczema develop and can lead to new treatments

  • The researchers created an “atlas” that examined 50,000 different skin cells
  • Identify the cellular mechanisms that cause chronic skin conditions
  • Many found are the same as in healthy cells and we hope that the database and discovery will allow future therapies to be developed.

For PA Media and Joe Pinkstone for Mailonline

Posted: | Updated:

Scientists in the UK have discovered how chronic skin conditions such as psoriasis and eczema develop.

Researchers at the University of Newcastle found that skin cells with eczema and psoriasis share many of the cellular mechanisms such as the development of healthy skin cells.

The team said the findings, published in the journal Science, could help in the development of new drugs targeting inflammatory skin diseases.

Researchers at the University of Newcastle found that skin cells with eczema and psoriasis share many of the cellular mechanisms such as the development of healthy skin cells.

Researchers at the University of Newcastle found that skin cells with eczema and psoriasis share many of the cellular mechanisms such as the development of healthy skin cells.

Psoriasis, which affects around two per cent of people in the UK, is caused by an increase in the production of skin cells.

Although the process is not fully understood, the disease is believed to be related to a problem with the immune system.

Eczema, which causes itching, dryness and cracking of the skin, is more common in children, but can improve as they grow older.

There is no cure for the conditions and treatments can only alleviate the symptoms.

The scientists created a detailed map of human skin as part of the global Atlas of Human Cells effort to map all cell types in the human body.

They examined how cells develop in healthy skin as well as in the skin of patients with eczema and psoriasis.

Psoriasis, which affects around two per cent of people in the UK, is caused by an increase in the production of skin cells. Although the process is not fully understood, the disease is believed to be related to an immune system problem.

Psoriasis, which affects around two per cent of people in the UK, is caused by an increase in the production of skin cells. Although the process is not fully understood, the disease is believed to be related to an immune system problem.

Facial masks can cause ECZEMA attacks in people with sensitive skin and allergies, the study warns

People with sensitive skin may be at risk for eczema triggered by the use of a face mask.

Doctors revealed that a 60-year-old man with a history of various skin allergies suffered a dermatitis attack caused by his mask.

After initially struggling to diagnose the root of the problem, doctors realized that it was the elastic bands on the face mask that were the cause.

The patient was diagnosed with a case of contact dermatitis, a form of eczema fueled by a reaction to a substance or material.

The American man received medication with prednisone, a common antiallergic drug, before the mask problem was detected.

But this was ineffective and the man later returned to his doctors with the problem.

After identifying the location of the face in the same place where a mask sits, doctors speculated that the fault would be the shape of the PPE.

Analysis of more than 500,000 skin cells revealed that diseased cells shared many of the same molecular pathways as developing cells.

Professor Muzlifah Haniffa, co-senior author at the University of Newcastle and an associate professor at the Wellcome Sanger Institute, said: “This Atlas of Skin Cells Reveals Specific Molecular Signals Sent by Developing Healthy Skin to Summon immune cells and form a protective layer.

“We were surprised to see that the skin cells of eczema and psoriasis sent the same molecular signals, which could overactivate the immune cells and cause the disease.

‘This had never been seen before. Discovering that developing cellular pathways reappear is a major leap in our understanding of inflammatory skin diseases and offers new avenues for finding treatments.

The researchers said their study also opens new avenues for research into other inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease and could have “major implications” for regenerative medicine, especially for to burn victims.

Professor Fiona Watt, co-author at Kings College London, said: “There has been decades of research on skin cells grown in the laboratory.

However, it is not always clear how the properties of cells in the laboratory change.

“By revealing the detailed composition of cells immediately isolated from developing and adult human skin, this Atlas of Skin Cells can act as a template for researchers trying to rebuild healthy skin in regenerative medicine.”

.Source