
Photographer: Nathan Laine / Bloomberg
Photographer: Nathan Laine / Bloomberg
Like all new drugs, vaccines authorized to protect against Covid-19 present some safety issues and side effects. Lots of people who have received the first two western shots deployed, one of Pfizer Inc. i BioNTech SE and another of Moderna Inc., has experienced fever, headache and pain at the injection site. These side effects usually go away quickly. More worryingly, Norway has it reported deaths among the elderly with serious health conditions following the administration of the Pfizer-BioNTech vaccine, possibly related to these side effects. Some other recipients of the various blows have had a severe but treatable allergic reaction, called anaphylaxis.
1. What is known about the dead?
Twenty-nine were reported in mid-January among some 40,000 people who received the Pfizer-BioNTech vaccine in Norway, where authorities have prioritized vaccination of residential residents. Those who died were all in the “75++” stretch (exact ages were not given for privacy reasons) and included patients with terminal illnesses who were expected to be only weeks or months old. All deaths that occur within a few days of vaccination are carefully assessed. People close to the time of vaccination are not necessarily because of the shot: an average of According to the Norwegian Medicines Agency, 400 people die every week in residences and long-term care centers. Sigurd Hortemo, the agency’s chief physician, said he cannot rule out that common adverse reactions to the vaccine, such as fever and nausea, could be potentially fatal in patients with serious underlying health problems.
2. Were there any deaths elsewhere?
In Germany, where more than 800,000 people have received the first of two doses of the Pfizer-BioNTech vaccine, the Paul Ehrlich Institute has investigated at least seven cases of elderly people dying shortly after vaccination. In his report, he said the deaths were probably due to the cause of the patients. underlying diseases such as carcinomas, kidney deficiencies and Alzheimer’s, not inoculation.
3. What reactions did these fatal cases develop?
The deaths were associated with Norway fever, nausea, and diarrhea: relatively common and short-lived effects that some people may experience after almost any vaccination, according to information from the Australian Therapeutic Administration. (He is working with the European Medicines Agency, which includes Norway, before deciding whether to approve the drug in Australia.) Reactions are not expected to be of significant importance in the vast majority of people. Millions of doses of the Pfizer-BioNTech vaccine have been administered United States, United Kingdom and some other countries with no deaths have been reported due to the vaccine, said Abrar Chughtai, a professor in the School of Public Health and Community Medicine at the University of New South Wales, at the Australian Science Media Center.
4. What is known about the risks of the vaccine in the elderly and frail?
Not much. Common adverse reactions to non-hazardous vaccines in younger, healthy patients may occur. aggravates the underlying disease in the elderly, Steinar Madsen, medical director of the Norwegian agency, told the medical journal BMJ. Only a limited number of people over the age of 85 participated in large clinical trials of the Pfizer-BioNTech vaccine, the agency said. The average participant in the trial for the two approved Western vaccines was about 50 years old.
5. What is done in response to deaths?
The Norwegian Institute of Public Health has updated its Covid-19 vaccination guide with more detailed advice on vaccinating the elderly who are vulnerable. “We are now asking doctors to continue with vaccination, but to do an additional assessment of very sick people who may aggravate their underlying condition,” Madsen said. The evaluation includes discussing the risks and benefits of vaccination with patients and their families to decide whether or not vaccination is prudent. Separately, neighboring Nordic Finland has recommended the systematic vaccination of patients with terminal illnesses the active treatment (ie those who are being palliated) has stopped. The reason is that common side effects like temporary fever can weaken your condition.
6. What other serious reactions have there been?
The body fights foreign invaders through various mechanisms that include the manufacture of protective proteins called antibodies, the release of toxins that kill microbes, and the control of guard cells to fight infection. As with any conflict, sometimes the effort to repel an infection can be detrimental. In rare cases, it can cause swelling and swelling of the tissues in a severe allergic reaction called anaphylaxis. As much as 5% of the American population has had this reaction to various substances. It can be fatal if, for example, the person’s airway is closed, even if there are deaths. rar. Allergies a insect bites and food can cause it, although it is the pharmacological reactions most common cause of anaphylaxis deaths in the US and UK
7. Where have the Covid-19 vaccine cases been caused?
According to a January 6 report from the U.S. Centers for Disease Control and Prevention, 21 cases of anaphylaxis associated with the Pfizer-BioNTech vaccine had been confirmed in the country on 23 December. Of these people, 17 had a documented history of allergies and seven had a history of anaphylaxis. A December 19th the CDC presentation referred to two cases in the UK associated with the same vaccine, and a month later in Israel, a man suffered an anaphylactic shock an hour after receiving it, according to the Jerusalem Post. He said he had had previous reactions to penicillin, the newspaper reported. CDC officials say they have also seen the reactions of recipients of the Moderna shooting and that they are collecting data on them.
8. Has anaphylaxis been connected to vaccines before?
Yes. These reactions occur approximately 1.3 times per million doses of flu vaccine administered. With other vaccines they have been seen at rates of 12 to 25 per million doses, although studies were reduced. According to the CDC, for the Pfizer-BioNTech Covid vaccine, the rate on December 23 is 11.1 per million doses, which is very low. The agency said the risk surrounding the vaccine is less than the risk of getting a severe case of Covid-19.
9. How long does the risk of allergic reaction last?
It is usually not long. Anaphylactic reactions usually occur within minutes to hours of exposure to a specific substance, said Michael Kinch, a drug development expert and associate vice president of University of Washington at St. Louis. So far in the United States, the lag ranged from two to 150 minutes, averaging 13 minutes, according to the CDC.
10. What is being done about it?
The United Kingdom and the U.S. has advised people who have allergies to any component of a Covid vaccine not to receive it. Anaphylaxis can be quickly combated with antihistamines along with adrenaline injectors such as Mylan NV’s Epi-Pen, which slows or stops immune reactions, and the health professionals who give the vaccine keep these items ready. These treatments do not negate the beneficial effects of vaccines. In the U.S., health care workers observe everyone receiving the vaccine at least 15 minutes after the injection to watch for signs of a reaction; people with a worrying history of allergic reaction are monitored twice as long. People who have had reactions to a first dose of vaccine should not receive a second, according to the CDC.
11. Do we know what causes reactions to prey?
This is not clear. The two main candidates are polyethylene glycol – a chemical found in many foods, cosmetics and medicines – and lipid nanoparticles that encapsulate messenger RNA, a genetic component of vaccines, according to Eric Topol, a clinical trial expert and director of the Scripps Research Translational Institute. Polyethylene glycol has been previously linked to a handful of cases of anaphylaxis. Once the cause is reduced, Covid vaccines may be even safer than current ones, Topol said.
The reference shelf
– With the assistance of Lars Erik Taraldsen and Kati Pohjanpalo